First TransPennine Express runs 60 routes.
- Train route between Barrow-in-Furness and Blackpool North
- Train route between Barrow-in-Furness and Lancaster
- Train route between Barrow-in-Furness and Manchester Airport
- Train route between Barrow-in-Furness and Preston
- Train route between Barrow-in-Furness and Windermere
- Train route between Blackpool North and Manchester Airport
- Train route between Blackpool North and Manchester Piccadilly
- Train route between Blackpool North and Preston
- Train route between Blackpool North and Windermere
- Train route between Carlisle and Edinburgh
- Train route between Carstairs and Edinburgh
- Train route between Cleethorpes and Manchester Airport
- Train route between Cleethorpes and Sheffield
- Train route between Doncaster and Manchester Airport
- Train route between Doncaster and Manchester Piccadilly
- Train route between Edinburgh and Manchester Airport
- Train route between Edinburgh and Manchester Piccadilly
- Train route between Glasgow Central and Manchester Airport
- Train route between Huddersfield and Hull
- Train route between Huddersfield and York